Retinal Biology Laboratory
Tailoi Chan-Ling
Research in this laboratory utilizes the unique advantages offered by the
retina to further the understanding of the developmental biology of glial
cells and the vasculature, as well as furthering our understanding of the
pathogenetic mechanisms underlying neurological disease.
Recent publications: 1. Chan-Ling T, Gock B and Stone J: The effect of oxygen on vasoformative cell division: Evidence that 'Physiological hypoxia' is the stimulus for normal retinal vasculogenesis. Invest Ophthalmol and Vis Sci 36: 1201-1214, 1995. 2. Chan-Ling T., Gock B. and Stone J.: Supplemental oxygen therapy: Basis for non-invasive treatment of retinopathy of prematurity. Invest Ophthalmol and Vis Sci. 36:1215-1230, 1995. 3. Stone J, Itin A, Alon T, Pe'er Y , Gnessin H, Chan-Ling T and Keshet E: Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J. Neuroscience. 15:4738-4747, 1995. 4. Invited review as the 1994 Australian Life Sciences Research awardee: Chan-Ling T: From Kittens to Babies: The gift of sight. Today's Life Science. 7:26-31, 1995 5. Medana L., Chan-Ling T. and Hunt NH: Redistribution and degeneration of retinal astrocytes in experimental murine cerebral malaria: relationship to disruption of the blood-retinal barrier. GLIA. 16:51-64, 1996. (Plus Cover Photo) 6. Stone J, Chan-Ling T, Pe'er J, Itin A, Gnessin H and Keshet E: Roles of VEGF and astrocyte degeneration in the genesis of retinopathy of prematurity. Invest Ophthalmol and Vis Sci. 37:290-299, 1996. 7. Ma N, Hunt N, Madigan M and Chan-Ling T: Correlation between enhanced vascular permeability, upregulation of cell adhesion molecules and monocyte adhesion in the retina during fatal murine cerebral malaria. Am J Path. 149:1745-1762, 1996. 8. Contribution by personal invitation: Chan-Ling T: Glial, neuronal and vascular cytogenesis in wholemounted cat retina. A special issue of Microscopy Research and Technique on retinal histology. 36:1-16, 1997. 9. Watanabe T, Voyvodic J, Chan-Ling T, Sagara H, Hirosawa K, Mio Y, Uchimura H, Nakahara K and Raff M: Differentiation and morphogenesis in pellet cultures of developing rat retinal cells. J. Comp Neurol 377:341-350, 1997. 10. Ma N. Madigan M, Chan-Ling T and Hunt N: Compromised blood-nerve barrier, astrogliosis, and myelin disruption in optic nerves during fatal murine cerebral malaria. GLIA. 19:135-151, 1997. 11. Medana L., Hunt N. and Chan-Ling T: Early activation of microglia in the pathogenesis of fatal murine cerebral malaria. (Plus cover photo) GLIA. 19:91-103, 1997. 12. Morcos Y and Chan-Ling T: Identification of oligodendrocyte precursors in the myelinated streak of the adult rabbit retina in vivo. GLIA. 21:163-182, 1997. 13. Hu P, Pollard J, Hunt N, Taylor J, and Chan-Ling T: Microvascular and cellular responses in the optic nerve of rats with acute experimental allergic encephalomyelitis (EAE). Brain Pathology. 8: 475-486, 1998. 14. Hu P, Pollard J, Hunt N and Chan-Ling T: Microvascular and cellular responses in the retina of rats with acute experimental allergic encephalomyelitis (EAE). Brain Pathology. 8: 487-498, 1998. 15. Morcos Y, Shorey CDS and Chan-Ling T: Contribution of O4+ oligodendrocyte precursors and astrocytes to the glial ensheathment of vessels in the rabbit myelinated streak. Glia . 27:1-14, 1999. 16. Medana I, Chan-Ling T and Hunt NH: Reactive changes of retinal microglia during fatal murine cerebral malaria: effects of dexamethasone and experimental permeabilisation of the blood-brain barrier. Am J Path. 156:1055-1065 17. Hughes S, Yang H, and Chan-Ling T: Vascularisation of the human fetal retina: Roles of vasculogenesis and angiogenesis. Invest Ophthalmol Vis Sci 41:1217-1228 18. Hu P, Pollard J and Chan-Ling T: Breakdown of the blood retinal barrier by activated T cells of non-neural specificity. Am J Path 156:1139-1149 (Plus Cover Photo) . 19. Hughes S and Chan-Ling T: Roles of endothelial cell migration and apoptosis in vascular remodelloing during development of the central nervous system. Microcirculation. 7, 317-333, 2000. 20. Morcos Y and Chan-Ling T; Astrocytes at the retinal-optic nerve junction prevent intraretinal myelination: comparative and developmental evidence. In Press Journal of Neurocytology 21. Morcos Y, Hosie MJ, Bauer HC and Chan-Ling T: Immunolocalisation of occludin and claudin-1 to tight junctions in intact CNS vessels. Under revision. Journal of Neurocytology 22. Chu Y, Hughes S, and Chan-Ling T: Astrocyte precursor cell (APCs) and astrocyte differentiation in embryonic human retina: Relevance to optic nerve colobomas. Submitted for publication FASEB J. INVITED REVIEWS 23. Chan-Ling T. and Stone J: Retinopathy of prematurity: Its origins in the architecture of the retina. In Progress in Retinal Research. Eds N. Osborne & G. Chader. Pergamon Press, Oxford. Vol 12, 155-178 1993. 24. Chan-Ling T: Glial, neuronal and vascular interactions in the mammalian retina. In Progress in Retinal Research. Eds N. Osborne & G. Chader. Pergamon Press, Oxford. Vol 13, 357-389 1994. 25. Chan-Ling T and Pye D: Pachometry: Clinical and scientific applications. In A textbook of Contact Lens Practice. Ed. Guillon M and Ruben M. Chapman and Hall, London. Chapter 1994 407-435. 26. Medana, I.M., Chaudhri, G Chan-Ling, T. & Hunt, N.H.: The central nervous system in cerebral malaria: "innocent bystander" or active participant in the induction of pathology? Immunology and Cell Biology. In Press.